Based on the real-life courtship between Pakistan-born aspiring comedian Kumail (Kumail Nanjiani), who connects with grad student Emily (Zoe Kazan) after one of his stand-up sets.
However, what they thought would be just a one-night stand blossoms into the real thing, which complicates the life that is expected of Kumail by his traditional Muslim parents. When Emily is beset with a mystery illness, it forces Kumail to navigate the medical crisis with her parents, Beth and Terry (Holly Hunter and Ray Romano) who he's never met, while dealing with the emotional tug-of-war between his family and his heart. The Big Sick finds plots by losing them. That's its genius. One moment we are in an ethnic satire; the next a rom-com; the next a hospital comedy-drama. But that's existence.